An interaction between gramicidin and the sigma subunit of RNA polymerase.

@article{Fisher1982AnIB,
  title={An interaction between gramicidin and the sigma subunit of RNA polymerase.},
  author={R. Fisher and T. Blumenthal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 4},
  pages={
          1045-8
        }
}
  • R. Fisher, T. Blumenthal
  • Published 1982
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Gramicidin, a peptide antibiotic produced by Bacillus brevis, inhibits initiation of transcription by RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6). We show here that the presence of gramicidin causes an increase in the rate of cleavage of the sigma subunit of Escherichia coli RNA polymerase by trypsin, although it does not alter the cleavage rate of any of the core subunits. Furthermore, whereas isolated sigma is cleaved much faster than is sigma in holoenzyme… CONTINUE READING
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