An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study

@inproceedings{Masuko2011AnIB,
  title={An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study},
  author={Hironori Masuko and Tohru Sakamoto and Yoshiko Kaneko and Hiroaki Iijima and Takashi Naito and Emiko Noguchi and Tomomitsu Hirota and Mayumi Tamari and Nobuyuki Hizawa},
  booktitle={BMC Medical Genetics},
  year={2011}
}
An Nrf2-dependent response is a central protective mechanism against oxidative stress. We propose that particular genetic variants of the Nrf2 gene may be associated with a rapid forced expiratory volume in one second (FEV1) decline induced by cigarette smoking. We conducted a retrospective cohort study of 915 Japanese from a general population. Values of annual decline in FEV1 were computed for each individual using a linear mixed-effect model. Multiple clinical characteristics were assessed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Level and course of FEV 1 in relation to polymorphisms in NFE 2 L 2 and KEAP 1 in the general population

  • M Siedlinski, DS Postma, +4 authors HM Boezen
  • Respir Res
  • 2009

Similar Papers

Loading similar papers…