An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm.

@article{Goering2003AnIN,
  title={An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm.},
  author={Lisa M Goering and Kazuyuki Hoshijima and Barbara Hug and Brent W Bisgrove and Andreas Kispert and David Jonah Grunwald},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 16},
  pages={9410-5}
}
T-box genes encode transcription factors that play critical roles in generating the vertebrate body plan. In many developmental fields, multiple T-box genes are expressed in overlapping domains, establishing broad regions in which different combinations of T-box genes are coexpressed. Here we demonstrate that three T-box genes expressed in the zebrafish mesoderm, no tail, spadetail, and tbx6, operate as a network of interacting genes to regulate region-specific gene expression and developmental… CONTINUE READING