An integrity assay for a meningococcal type B conjugate vaccine.

@article{Turula2004AnIA,
  title={An integrity assay for a meningococcal type B conjugate vaccine.},
  author={Vincent E Turula and John Y.H. Kim and Francis Michon and James Pankratz and Yuwen Zhang and Chul Yoo},
  journal={Analytical biochemistry},
  year={2004},
  volume={327 2},
  pages={261-70}
}
The development of an analytical procedure for the evaluation of a conjugate vaccine's structural wholeness or integrity is described. The principle component of the vaccine was the N-propionylated group B meningococcal polysaccharide (NPr-GBMP) covalently attached to a carrier protein. The goal of the procedure was to determine whether any whole polysaccharide, oligosaccharide, or monosaccharide, from minute to moderate levels, became detached off the conjugate. Free saccharide was isolated… CONTINUE READING