An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.

@article{Oxley2008AnIP,
  title={An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.},
  author={Camilla L Oxley and Nicholas J. Anthis and Edward D. Lowe and Ioannis Vakonakis and Iain D. Campbell and Kate L Wegener},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 9},
  pages={5420-6}
}
Integrins play a fundamental role in cell migration and adhesion; knowledge of how they are regulated and controlled is vital for understanding these processes. Recent work showed that Dok1 negatively regulates integrin activation, presumably by competition with talin. To understand how this occurs, we used NMR spectroscopy and x-ray crystallography to investigate the molecular details of interactions with integrins. The binding affinities of beta3 integrin tails for the Dok1 and talin… CONTINUE READING

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