An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.

@article{Deakin2009AnIT,
  title={An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.},
  author={Nicholas O. Deakin and Mark D Bass and Stacey Warwood and Julia Schoelermann and Zohreh Mostafavi-Pour and David E O Knight and Christoph Ballestrem and Martin J Humphries},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 10},
  pages={1654-64}
}
Alpha4 integrins are used by leukocytes and neural crest derivatives for adhesion and migration during embryogenesis, immune responses and tumour invasion. The pro-migratory activity of alpha4 integrin is mediated in part through the direct binding of the cytoplasmic domain to paxillin. Here, using intermolecular FRET and biochemical analyses, we report a novel interaction of the alpha4 integrin cytoplasmic domain with 14-3-3zeta. This interaction depends on serine phosphorylation of alpha4… CONTINUE READING