An integrative theory of prefrontal cortex function.

  title={An integrative theory of prefrontal cortex function.},
  author={Earl K. Miller and Jonathan D. Cohen},
  journal={Annual review of neuroscience},
The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of… 

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