An integrative theory of prefrontal cortex function.

@article{Miller2001AnIT,
  title={An integrative theory of prefrontal cortex function.},
  author={Earl K. Miller and J. D. Cohen},
  journal={Annual review of neuroscience},
  year={2001},
  volume={24},
  pages={
          167-202
        }
}
The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of… Expand
Cognitive Control (Executive Function): Role of Prefrontal Cortex
Cognitive control is the ability to direct mental function and behavior in accord with internally represented intentions or goals. This ability is fundamental to all higher cognitive faculties, suchExpand
The Architecture of Cognitive Control in the Human Prefrontal Cortex
TLDR
Using brain imaging in humans, it is shown that the lateral PFC is organized as a cascade of executive processes from premotor to anterior PFC regions that control behavior according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur, respectively. Expand
An information theoretical approach to prefrontal executive function
TLDR
A theory that draws upon concepts from information theory to describe the architecture of executive control in the lateral prefrontal cortex is proposed, which clarifies how executive control can operate as a unitary function, despite the requirement that information be integrated across multiple distinct, functionally specialized prefrontal regions. Expand
Doping the Mind
  • A. Ranganath, S. N. Jacob
  • Psychology, Medicine
  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2016
TLDR
The crucial role dopamine plays as a modulator of prefrontal cognitive functions, in the primate brain in particular, is reviewed, and how unregulated prefrontal dopamine signaling could contribute to major disorders of cognition is discussed. Expand
The gateway hypothesis of rostral prefrontal cortex (area 10) function
TLDR
Investigations into the functions of rostral PFC will reveal key new insights into how human and non-human mental abilities differ, including the 'thoughts in the authors' head'). Expand
Prefrontal Executive Functions Predict and Preadapt
Abstract The prefrontal cortex plays a critical role in the temporal organization of behavior and language within the broad neurobiological framework of the perception–action (PA) cycle, the circularExpand
Insights into Human Behavior from Lesions to the Prefrontal Cortex
TLDR
A broad overview of PFC functions based on behavioral and neural changes resulting from damage to PFC in both human patients and nonhuman primates is provided. Expand
Conflict and Cognitive Control in the Brain
Recent research from cognitive psychology and cognitive neuroscience has suggested that the control mechanisms by which people are able to regulate task performance can be dissociated into evaluativeExpand
Dopamine and Cognitive Control in Prefrontal Cortex
TLDR
This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands. Expand
The Role of the Medial Frontal Cortex in Cognitive Control
TLDR
New findings in cognitive neuroscience concerning cortical interactions that subserve the recruitment and implementation of cognitive control are evaluated, suggesting that monitoring-related pMFC activity serves as a signal that engages regulatory processes in the LPFC to implement performance adjustments. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 236 REFERENCES
A Computational Model of Prefrontal Cortex Function
TLDR
A new behavioral task and a computational model are presented and the model is used to make novel and testable predictions regarding the behavioral performance of schizophrenics, who are hypothesized to suffer from reduced dopaminergic tone in this brain area. Expand
A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges.
  • J. Cohen, T. Braver, R. O'Reilly
  • Psychology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
TLDR
The value of a computational approach for understanding the mechanisms responsible for cognitive control, at both the neural and psychological levels, and the specific manner in which they break down in schizophrenia is illustrated. Expand
Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.
TLDR
Event-related functional magnetic resonance imaging and a task-switching version of the Stroop task were used to examine whether these components of cognitive control have distinct neural bases in the human brain and a double dissociation was found. Expand
The prefrontal cortex, mediator of cross-temporal contingencies.
  • J. Fuster
  • Psychology, Medicine
  • Human neurobiology
  • 1985
TLDR
It is concluded that the prefrontal cortex subserves at least three cognitive functions that allow the mediation of cross-temporal contingencies and, thereby, the formation of temporally extended structures of behavior: short-term memory, preparatory set, and control of interference. Expand
The Prefrontal Cortex Complex Neural Properties for Complex Behavior
TLDR
The extensive connections and ability of its neurons to be modified by experience may allow the PF cortex to play a role in knitting together behaviorally relevant associations, a process needed for acquisition of “rules” that guide goal-directed behavior. Expand
The role of the anterior prefrontal cortex in human cognition
TLDR
The results indicate that the fronto-polar prefrontal cortex selectively mediates the human ability to hold in mind goals while exploring and processing secondary goals, a process generally required in planning and reasoning. Expand
Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia.
TLDR
A disturbance in the internal representation of contextual information can provide a common explanation for schizophrenic deficits in several attention- and language-related tasks and shows that these behavioral deficits may arise from a disturbance in a model parameter corresponding to the neuromodulatory effects of dopamine. Expand
Dissociation in prefrontal cortex of affective and attentional shifts
TLDR
It is demonstrated that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory Control in different aspects of cognitive processing. Expand
Neural Activity in the Primate Prefrontal Cortex during Associative Learning
TLDR
It is found that the activity of individual PF neurons represented both the cues and the associated responses, perhaps providing a neural substrate for their association during learning. Expand
Neural correlates of motor memory consolidation.
TLDR
Functional imaging of the brain demonstrates that within 6 hours after completion of practice, while performance remains unchanged, the brain engages new regions to perform the task; there is a shift from prefrontal regions of the cortex to the premotor, posterior parietal, and cerebellar cortex structures, specific to recall of an established motor skill. Expand
...
1
2
3
4
5
...