An integrative theory of prefrontal cortex function.

  title={An integrative theory of prefrontal cortex function.},
  author={E. Miller and J. Cohen},
  journal={Annual review of neuroscience},
  • E. Miller, J. Cohen
  • Published 2001
  • Medicine, Psychology
  • Annual review of neuroscience
  • The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of… CONTINUE READING

    Figures and Topics from this paper.

    Paper Mentions

    Biogenetic messages about the etiology of mental illness (e.g., the "chemical imbalance theory" of depression) are increasing but the impact that these have on decision-making and… Expand
    ConditionsMajor Depressive Disorder
    Inhibition and the right inferior frontal cortex
    • 2,572
    • PDF
    Saliency, switching, attention and control: a network model of insula function
    • 2,939
    • PDF
    Working memory.
    • 8,712
    • PDF
    An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.
    • 2,555
    • PDF
    The Reorienting System of the Human Brain: From Environment to Theory of Mind
    • 2,552
    • PDF


    Publications referenced by this paper.
    Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.
    • 3,240
    • PDF
    Parallel organization of functionally segregated circuits linking basal ganglia and cortex.
    • 7,322
    • PDF
    Insensitivity to future consequences following damage to human prefrontal cortex
    • 4,855
    • PDF
    Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.
    • 4,881
    • PDF
    A feature-integration theory of attention
    • 10,681
    • PDF
    The magical number seven plus or minus two: some limits on our capacity for processing information.
    • 19,705
    • PDF
    Anterior cingulate cortex, error detection, and the online monitoring of performance.
    • 3,036
    • PDF
    The Prefrontal Cortex
    • 2,500
    • PDF
    Conflict monitoring versus selection-for-action in anterior cingulate cortex
    • 1,859