An integrative theory of prefrontal cortex function.

@article{Miller2001AnIT,
  title={An integrative theory of prefrontal cortex function.},
  author={E. Miller and J. Cohen},
  journal={Annual review of neuroscience},
  year={2001},
  volume={24},
  pages={
          167-202
        }
}
  • E. Miller, J. Cohen
  • Published 2001
  • Psychology, Medicine
  • Annual review of neuroscience
  • The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of… CONTINUE READING
    9,607 Citations

    Figures and Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    Biogenetic messages about the etiology of mental illness (e.g., the "chemical imbalance theory" of depression) are increasing but the impact that these have on decision-making and… Expand
    ConditionsMajor Depressive Disorder
    InterventionOther
    An information theoretical approach to prefrontal executive function
    • 844
    • PDF
    Doping the Mind
    • A. Ranganath, S. N. Jacob
    • Psychology, Medicine
    • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
    • 2016
    • 4
    • PDF
    The gateway hypothesis of rostral prefrontal cortex (area 10) function
    • 649
    • PDF
    Insights into Human Behavior from Lesions to the Prefrontal Cortex
    • 224
    • PDF
    Conflict and Cognitive Control in the Brain
    • 177
    Dopamine and Cognitive Control in Prefrontal Cortex
    • 68
    • PDF

    References

    SHOWING 1-10 OF 236 REFERENCES
    A Computational Model of Prefrontal Cortex Function
    • 46
    • PDF
    A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges.
    • J. Cohen, T. Braver, R. O'Reilly
    • Psychology, Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 1996
    • 477
    Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.
    • 3,320
    • PDF
    The prefrontal cortex, mediator of cross-temporal contingencies.
    • J. Fuster
    • Psychology, Medicine
    • Human neurobiology
    • 1985
    • 298
    The Prefrontal Cortex Complex Neural Properties for Complex Behavior
    • 259
    Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia.
    • 1,447
    • PDF
    Dissociation in prefrontal cortex of affective and attentional shifts
    • 1,414
    Neural Activity in the Primate Prefrontal Cortex during Associative Learning
    • 534
    • PDF
    Neural correlates of motor memory consolidation.
    • 931
    • PDF