An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.

@article{AstonJones2005AnIT,
  title={An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.},
  author={Gary Aston-Jones and Jonathan D. Cohen},
  journal={Annual review of neuroscience},
  year={2005},
  volume={28},
  pages={
          403-50
        }
}
Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously thought. We review neurophysiological and modeling studies in monkey that support a new theory of LC-NE function. LC neurons exhibit two modes of activity, phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is… Expand
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance
TLDR
It is proposed that prefrontal areas of the locus coeruleus–norepinephrine system produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales. Expand
DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting
TLDR
The experiments sought to exogenously induce an elevated pattern of activity in LC neurons and their medial prefrontal cortical (mPFC) targets to test the tenets of the Adaptive Gain Theory (AGT) of LC function, and extend the understanding of the role of LC in PFC and flexible behavior. Expand
Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets
TLDR
New evidence suggests that the modular input-output organization of the LC could enable transient, task-specific modulation of distinct brain regions, and future work must further assess whether this spatial modularity coincides with functional differences in LC-NE subpopulations acting at specific times, and how such spatiotemporal specificity might influence learned behaviors. Expand
Modafinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI
TLDR
The pharmacological agent modafinil was used to promote low-tonic/high-phasic LC-NE activity in healthy humans performing a cognitive control task during event-related functional magnetic resonance imaging (fMRI). Expand
Functional specificity of the locus coeruleus-norepinephrine system in the attentional networks
TLDR
The reported results seem to suggest that Pa characterizes both alerting and orienting processes, since the temporally informative (alerting) double-cue evoked larger Pa amplitude compared to the no-cue condition, whereas the temporalally-and-spatially informative cue additionally accelerated Pa activation compared toThe alerting cue. Expand
The Neuroscience of the Flow State: Involvement of the Locus Coeruleus Norepinephrine System
TLDR
It is argued that knowledge about the role of the LC-NE system in establishing the flow experience may help to gain fundamental knowledge of flow and can contribute to unifying various empirical findings on this topic. Expand
Role of the locus coeruleus arousal system in cognitive control
TLDR
Empirical evidence is provided for a decisive role of the locus coeruleus noradrenergic arousal system in cognitive control in humans and novel insight into arousal‐related influences on cognitive control is provided. Expand
Locus Coeruleus Engagement Drives Network Connectivity Dynamics In Humans And Rats
TLDR
Examining how LC engagement impacted BOLD and functional connectivity variability and dynamics in resting state and attentional networks in humans and rats provides preliminary cross-species evidence suggesting that LC’s computational role in regulating performance may rest largely on its role in regulation. Expand
Context-Dependent Relationships between Locus Coeruleus Firing Patterns and Coordinated Neural Activity in the Anterior Cingulate Cortex
TLDR
The results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system. Expand
Locus Coeruleus Phasic, But Not Tonic, Activation Initiates Global Remapping in a Familiar Environment
TLDR
The results support a role for phasic LC responses in generating novel hippocampal sequences during memory encoding and, potentially, memory updating and strengthen the view that internal states are major determinants of the brain's construction of environmental representations. Expand
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