• Corpus ID: 2927068

An integrative statistical model for inferring strain admixture within clinical Plasmodium falciparum isolates

@article{OBrien2015AnIS,
  title={An integrative statistical model for inferring strain admixture within clinical Plasmodium falciparum isolates},
  author={John D. O'Brien and Zamin Iqbal and Lucas N Amenga-Etego},
  journal={arXiv: Applications},
  year={2015}
}
Since the arrival of genetic typing methods in the late 1960's, researchers have puzzled at the clinical consequence of observed strain mixtures within clinical isolates of Plasmodium falciparum. We present a new statistical model that infers the number of strains present and the amount of admixture with the local population (panmixia) using whole-genome sequence data. The model provides a rigorous statistical approach to inferring these quantities as well as the proportions of the strains… 

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