An integrative scoring system for ranking SNPs by their potential deleterious effects

@article{Lee2009AnIS,
  title={An integrative scoring system for ranking SNPs by their potential deleterious effects},
  author={Phil Hyoun Lee and Hagit Shatkay},
  journal={Bioinformatics},
  year={2009},
  volume={25 8},
  pages={1048-55}
}
MOTIVATION Identifying single nucleotide polymorphisms (SNPs) that underlie common and complex human diseases, such as cancer, is of major interest in current molecular epidemiology. Nevertheless, the tremendous number of SNPs on the human genome requires computational methods for prioritizing SNPs according to their potentially deleterious effects to human health, and as such, for expediting genotyping and analysis. As of yet, little has been done to quantitatively assess the possible… CONTINUE READING
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