An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

@article{Mestdagh2010AnIG,
  title={An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours},
  author={Pieter Mestdagh and Erik Fredlund and Filip Pattyn and Ali Rihani and Tom Van Maerken and Jo{\"e}lle Vermeulen and Candy Kumps and Bj{\"o}rn Menten and Katleen De Preter and Alexander Schramm and Johannes Hubertus Schulte and Rosa Noguera and Gudrun Schleiermacher and Isabelle Janoueix-Lerosey and Genevi{\'e}ve Laureys and Ralph M Powel and David Nittner and J-C Marine and Markus Ringn{\'e}r and Frank Speleman and Jo Vandesompele},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={3583-3592}
}
Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression profiling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach… CONTINUE READING