An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

@article{Natrajan2009AnIG,
  title={An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers},
  author={Rachael Natrajan and Britta Weigelt and Alan Mackay and Felipe C. Geyer and Anita Grigoriadis and David S. P. Tan and Debra J. Rose and Christopher J. Lord and Radost Vatcheva and Socorro M. Rodriguez-Pinilla and Jos{\'e} Palacios and Alan Ashworth and Jorge S. Reis-Filho},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={121},
  pages={575-589}
}
  • Rachael Natrajan, Britta Weigelt, +10 authors Jorge S. Reis-Filho
  • Published in Breast Cancer Research and Treatment 2009
  • DOI:10.1007/s10549-009-0501-3
Breast cancer is a heterogeneous disease caused by the accumulation of genetic changes in neoplastic cells. We hypothesised that molecular subtypes of breast cancer may be driven by specific constellations of genes whose expression is regulated by gene copy number aberrations. To address this question, we analysed a series of 48 microdissected grade III ductal carcinomas using high resolution microarray comparative genomic hybridisation and mRNA expression arrays. There were 5,931 genes whose… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 101 CITATIONS, ESTIMATED 48% COVERAGE

Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers

  • Breast Cancer Research
  • 2012
VIEW 22 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Functional viability profiles of breast cancer.

  • Cancer discovery
  • 2011
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

From integrative genomics to therapeutic targets.

  • Cancer research
  • 2013
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Genomic characterisation of acral melanoma cell lines.

  • Pigment cell & melanoma research
  • 2012
VIEW 2 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study

Konstantin J. Dedes, Maria-Angeles Lopez-Garcia, +8 authors Jorge S. Reis-Filho
  • Breast Cancer Research and Treatment
  • 2010
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Genetic alterations and oncogenic pathways associated with breast cancer subtypes.

  • Molecular cancer research : MCR
  • 2009
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2009
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL

Tiling path genomic profiling of grade 3 invasive ductal breast cancers.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2009
VIEW 19 EXCERPTS
HIGHLY INFLUENTIAL

Supervised risk predictor of breast cancer based on intrinsic subtypes.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL