An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer

Abstract

Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors; however, the molecular bases of their oncogenic properties are largely unknown. As TF activities are difficult to inhibit directly with small molecules, the genes and pathways they regulate might represent more… (More)
DOI: 10.1038/onc.2013.517

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