An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid

  title={An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid},
  author={Farshad Tehrani and Hazhir Teymourian and Brian Wuerstle and Jonathan Kavner and Ravi Patel and Allison Furmidge and Reza Aghavali and Hamed Hosseini-Toudeshki and Christopher Brown and Fangyu Zhang and Kuldeep Mahato and Zhengxing Li and Abbas Barfidokht and Lu Yin and Paul Warren and Nickey Huang and Zina Patel and Patrick P. Mercier and Joseph Wang},
  journal={Nature Biomedical Engineering},
  pages={1214 - 1224}
Implementations of wearable microneedle-based arrays of sensors for the monitoring of multiple biomarkers in interstitial fluid have lacked system integration and evidence of robust analytical performance. Here we report the development and testing of a fully integrated wearable array of microneedles for the wireless and continuous real-time sensing of two metabolites (lactate and glucose, or alcohol and glucose) in the interstitial fluid of volunteers performing common daily activities. The… 

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