An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells.

  • Jaime Miquel
  • Published 1991 in Archives of gerontology and geriatrics

Abstract

We maintain that aging of humans and animals derives from a mutation or inactivation (probably followed by endonuclease digestion) of the mitochondrial genome of differentiated cells. This extranuclear somatic mutation hypothesis of aging is based on the finding that mitochondrial DNA (mtDNA) synthesis takes place at the inner mitochondrial membrane near… (More)

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