An integrated regulatory network controlling survival and migration in thyroid organogenesis.

  title={An integrated regulatory network controlling survival and migration in thyroid organogenesis.},
  author={Rosanna Parlato and Annamaria Rosica and Alina Rodr{\'i}guez-Mall{\'o}n and Andrea Affuso and Maria Pia Postiglione and Claudio Arra and Ahmed Mansouri and Shioko Kimura and Roberto Di Lauro and Mario De Felice},
  journal={Developmental biology},
  volume={276 2},
The thyroid gland originates from the ventral floor of the foregut as a thickening of the endodermal cell layer. The molecular mechanisms underlying the early steps of thyroid morphogenesis are not known. Gene targeting experiments have contributed to the identification of several transcription factors, in general playing a role in the proliferation, survival, and migration of the thyroid cell precursors. The experiments reported here analyze the expression of the transcription factors Titf1… CONTINUE READING


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