An integrated proteomics and genomics analysis to unravel a heterogeneous platelet secretion defect.

@article{Michele2011AnIP,
  title={An integrated proteomics and genomics analysis to unravel a heterogeneous platelet secretion defect.},
  author={Michela Di Michele and Chantal Thys and Etienne Waelkens and Lut Overbergh and Wannes D'Hertog and Chantal Mathieu and R De vos and Kathelijne Peerlinck and Christel A Van Geet and Kathleen Freson},
  journal={Journal of proteomics},
  year={2011},
  volume={74 6},
  pages={
          902-13
        }
}
Eight patients with clinical bleeding problems have evidence for platelet storage pool disease as they present with impaired platelet aggregation and secretion with low concentrations of ADP and collagen and an absence of second phase aggregation with epinephrine. Electron microscopy analysis further showed a reduced but not absent amount of platelet dense granules, and CD63 staining was decreased compared to healthy controls. The presence of alpha granules and CD62P expression after platelet… CONTINUE READING
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