An integrated process for measuring the physicochemical properties of drug candidates in a preclinical discovery environment.

@article{Kibbey2001AnIP,
  title={An integrated process for measuring the physicochemical properties of drug candidates in a preclinical discovery environment.},
  author={Christopher E. Kibbey and Salwa K. Poole and Brian Robinson and Joshua D. Jackson and Dianne Durham},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 8},
  pages={1164-75}
}
Automated log P, pK(a), solubility, and chemical stability systems comprise an integrated process that provides early stage physicochemical property data to the discovery research organization. Capillary electrophoresis (CE) techniques are used to experimentally determine pK(a) and log P. Solubility is determined using a quasi-equilibrium approach employing sample quantitation by flow injection analysis with ultraviolet (UV) detection at 256 nm. Chemical stability is assessed by challenging… CONTINUE READING

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