An integrated model for haemorrhagic and ischaemic lesions in the newborn brain.

@article{Wigglesworth1978AnIM,
  title={An integrated model for haemorrhagic and ischaemic lesions in the newborn brain.},
  author={Jonathan S. Wigglesworth and Karen E Pape},
  journal={Early human development},
  year={1978},
  volume={2 2},
  pages={179-99}
}
The vascular anatomy of the developing brain changes from a predominantly basal ganglia orientated pattern at 24 wk to a cortically orientated pattern by 34 wk. This information, combined with other known data on cerebral vascular anatomy and physiology, allows us to develop a model for haemorrhagic and ischaemic lesions in the newborn brain based on two main series of reactions. One series involves the effects of hypoxia and hypercapnia in leading to breakdown of the blood--brain barrier with… CONTINUE READING
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