An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations.

@article{Silber2007AnIM,
  title={An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations.},
  author={Hanna E. Silber and Petra M Jauslin and Nicolas Frei dit Frey and R. Gieschke and Ulrika S H Simonsson and Mats O. Karlsson},
  journal={Journal of clinical pharmacology},
  year={2007},
  volume={47 9},
  pages={1159-71}
}
An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients was developed. Data from 72 individuals were included. Total glucose, labeled glucose, and insulin concentrations were determined. Simultaneous analysis of all data by nonlinear mixed effect modeling was performed in NONMEM. Integrated models for glucose, labeled glucose, and insulin were developed. Control mechanisms for… CONTINUE READING