An integrated methodology for mining promiscuous proteins: a case study of an integrative bioinformatics approach for hepatitis C virus non-structural 5A protein.


A methodology for elucidation of structural, functional, and mechanistic knowledge on promiscuous proteins is proposed that constitutes a workflow of integrated bioinformatics analysis. Sequence alignments with closely related homologues can reveal conserved regions which are functionally important. Scanning protein motif databases, along with secondary and… (More)
DOI: 10.1007/978-1-4419-5913-3_34