An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

@article{Nelson2012AnIF,
  title={An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.},
  author={Andrew C. Nelson and Nischalan Pillay and Stephen Henderson and Nad{\`e}ge Presneau and Roberto Tirabosco and Dina Halai and Fitim Berisha and Paul Flicek and Derek L. Stemple and Claudio D Stern and Fiona C. Wardle and Adrienne Margaret Flanagan},
  journal={The Journal of pathology},
  year={2012},
  volume={228 3},
  pages={
          274-85
        }
}
Chordoma is a rare malignant tumour of bone, the molecular marker of which is the expression of the transcription factor, brachyury. Having recently demonstrated that silencing brachyury induces growth arrest in a chordoma cell line, we now seek to identify its downstream target genes. Here we use an integrated functional genomics approach involving shRNA-mediated brachyury knockdown, gene expression microarray, ChIP-seq experiments, and bioinformatics analysis to achieve this goal. We confirm… CONTINUE READING

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