An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.

@article{Echalier2012AnIC,
  title={An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.},
  author={Aude Echalier and Emilie Cot and Alain Camasses and Elsie Hodimont and François Hoh and Philippe Jay and Felix B Sheinerman and Liliana Krasinska and Daniel G Fisher},
  journal={Chemistry & biology},
  year={2012},
  volume={19 8},
  pages={1028-40}
}
Cdk2 promotes DNA replication and is a promising cancer therapeutic target, but its functions appear redundant with Cdk1, an essential Cdk affected by most Cdk2 inhibitors. Here, we present an integrated multidisciplinary approach to address Cdk redundancy. Mathematical modeling of enzymology data predicted conditions allowing selective chemical Cdk2 inhibition. Together with experiments in Xenopus egg extracts, this supports a rate-limiting role for Cdk2 in DNA replication. To confirm this we… CONTINUE READING
Highly Cited
This paper has 21 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…