An integrated approach of network-based systems biology, molecular docking, and molecular dynamics approach to unravel the role of existing antiviral molecules against AIDS-associated cancer
@article{Omer2017AnIA, title={An integrated approach of network-based systems biology, molecular docking, and molecular dynamics approach to unravel the role of existing antiviral molecules against AIDS-associated cancer}, author={Ankur Omer and P. Singh}, journal={Journal of Biomolecular Structure and Dynamics}, year={2017}, volume={35}, pages={1547 - 1558} }
A serious challenge in cancer treatment is to reposition the activity of various already known drug candidates against cancer. There is a need to rewrite and systematically analyze the detailed mechanistic aspect of cellular networks to gain insight into the novel role played by various molecules. Most Human Immunodeficiency Virus infection-associated cancers are caused by oncogenic viruses like Human Papilloma Viruses and Epstein–Bar Virus. As the onset of AIDS-associated cancers marks the… CONTINUE READING
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References
SHOWING 1-10 OF 35 REFERENCES
Drug Targets for Cell Cycle Dysregulators in Leukemogenesis: In Silico Docking Studies
- Biology, Medicine
- PloS one
- 2014
- 9
- Highly Influential
- PDF
Identification of new candidate drugs for lung cancer using chemical–chemical interactions, chemical–protein interactions and a K-means clustering algorithm
- Medicine
- Journal of biomolecular structure & dynamics
- 2016
- 16
HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
- Medicine, Biology
- Journal of experimental & clinical cancer research : CR
- 2008
- 61
Predicting drug-target interaction in cancers using homology modeled structures of MTHFR gene
- Biology
- 2011
- 7
- PDF
Molecular aspects on adriamycin interaction with hmga1 regulatory region and its inhibitory effect on HMGA1 expression in human cervical cancer
- Biology, Medicine
- Journal of biomolecular structure & dynamics
- 2016
- 2
A robustness-based approach to systems-oriented drug design
- Biology, Medicine
- Nature Reviews Drug Discovery
- 2007
- 469
Thioredoxin System: A Model for Determining Novel Lead Molecules for Breast Cancer Chemotherapy
- Medicine, Biology
- Avicenna journal of medical biotechnology
- 2012
- 7
- Highly Influential
- PDF