An integrated approach for prospectively investigating a mode-of-action for rodent liver effects.

@article{LeBaron2013AnIA,
  title={An integrated approach for prospectively investigating a mode-of-action for rodent liver effects.},
  author={Matthew J. LeBaron and David R. Geter and Reza J. Rasoulpour and B. Bhaskar Gollapudi and Johnson Thomas and Jennifer Murray and H Lynn Kan and Amanda J Wood and Cliff R Elcombe and Audrey W Vardy and Jillian McEwan and Claire Terry and Richard Billington},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={270 2},
  pages={164-73}
}
Registration of new plant protection products (e.g., herbicide, insecticide, or fungicide) requires comprehensive mammalian toxicity evaluation including carcinogenicity studies in two species. The outcome of the carcinogenicity testing has a significant bearing on the overall human health risk assessment of the substance and, consequently, approved uses for different crops across geographies. In order to understand the relevance of a specific tumor finding to human health, a systematic… CONTINUE READING

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