An integrated analysis of differential miRNA and mRNA expressions in human gallstones.

  title={An integrated analysis of differential miRNA and mRNA expressions in human gallstones.},
  author={Bin Yang and Bing Liu and Pinduan Bi and Tao Wu and Qiang Wang and Jie Zhang},
  journal={Molecular bioSystems},
  volume={11 4},
Gallstone disease, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we investigated miRNA and mRNA involved in the formation of gallstones, and explored the molecular mechanisms in the development of gallstones. Differentially expressed 17 miRNAs and 525 mRNA were identified based on Illumina sequencing from gallbladder mucosa of patients with or without gallstones, and were validated by randomly selected 6 miRNAs and 8 genes… CONTINUE READING
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