An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells.

Abstract

Here, we characterize a transmembrane protein of the nuclear envelope that we name spindle-associated membrane protein 1 (Samp1). The protein is conserved in metazoa and fission yeast and is homologous to Net5 in rat and Ima1 in Schizosaccharomyces pombe. We show that, in human cells, the protein is a membrane-spanning polypeptide with an apparent molecular… (More)
DOI: 10.1242/jcs.047373

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