An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.

@article{Nisar2011AnIP,
  title={An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.},
  author={Shaista P. Nisar and Martina E. Daly and Augusto B Federici and Andrea Artoni and Andrew Mumford and Stephen P. Watson and Stuart James Mundell},
  journal={Blood},
  year={2011},
  volume={118 20},
  pages={
          5641-51
        }
}
The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after deletion or mutation of the 4 amino acids at the extreme C-terminus of this receptor (ETPM), a putative postsynaptic density 95/disc large/zonula occludens-1 (PDZ)-binding motif. In cell line models… CONTINUE READING

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G protein - coupled receptor sorting to endosomes and lysosomes

SS Smyth, DS Woulfe, JI Weitz
  • Annu Rev Pharmacol Toxicol
  • 2008

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