An insight into hexamethylenetetramine: a versatile reagent in organic synthesis

  title={An insight into hexamethylenetetramine: a versatile reagent in organic synthesis},
  author={Navjeet Kaur and Dharma Kishore},
  journal={Journal of the Iranian Chemical Society},
  • N. Kaur, D. Kishore
  • Published 18 April 2013
  • Chemistry
  • Journal of the Iranian Chemical Society
Hexamethylenetetramine is a versatile reagent in organic synthesis. It plays a major role in modern organic synthesis. This review focuses on hexamine reagent for its significant role in organic synthesis during the past decades and is able to provide a valuable perspective from synthetic point of view. 
14 Citations
Hexamethylenetetramine as an Efficient and Reusable Organocatalyst in Henry Reaction Under Mild and Aqueous Solution
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Hexamethylenetetramine as an efficient and reusable organocatalyst in Henry reaction under mild and aqueous solution
Henry reaction is a base catalyzed reaction which can produce β-nitroalcohol or nitroethylene derivatives from the condensation of aryl aldehydes and nitromethane under different conditions. In the
Photochemical reactions in five and six-membered polyheterocycles synthesis
Abstract Heterocycles are present in the drugs and pesticides in a major proportion and development of new strategies for the synthesis of these compounds is attractive topic for the synthetic and
Photochemical irradiation: Seven and higher membered O-heterocycles
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  • 2018
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Cobalt-catalyzed C–N, C–O, C–S bond formation: synthesis of heterocycles
  • N. Kaur
  • Chemistry
    Journal of the Iranian Chemical Society
  • 2019
In recent decades, a large number of reports related to the synthesis of N-, O- and S-containing heterocycles have appeared owing to a wide variety of their biological activity. Traditional
Synthesis of seven and higher membered nitrogen containing heterocycles using photochemical irradiation
  • N. Kaur
  • Chemistry
    Synthetic Communications
  • 2018
Abstract Photochemical reactions have been applied for the synthesis of complex targets in many examples recently. In many cases, these processes provide access to unique modes of reactivity or offer
Synthesis and heterogeneous catalytic activity of covalently immobilized hexamine cation as a magnetically-recoverable nanocatalyst
Functionalized magnetic core–shell nanoparticles Fe3O4-SiO2-HMTA are prepared by co-precipitation method and characterized by SEM, TEM, FT-IR, XRD, and VSM. The particles are spherical with an
Modelling of the Effect of Concentrated Nitration Conditions on the Efficiency of the Production of 3,7-Dinitro-1,3,5,7-tetraazabicyclo[3,3,1]nonane (DPT)
Table S2. Data of chromatograms obtained for DPT containing HMX and α-HMX The chromatogram obtained for DPT (28.3979 g) containing HMX (0.0156 g) (Figure 6S) Region Retention time (min) related to 1
Test purchase, identification and synthesis of 2-amino-1-(4-bromo-2, 5-dimethoxyphenyl)ethan-1-one (bk-2C-B).
A test purchase of 2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one was carried out and its identity was confirmed by a range of analytical techniques including nuclear magnetic resonance spectroscopy, gas and liquid chromatography, and high-resolution mass spectrometry.
Interfacial properties and impact toughness of dendritic hexamethylenetetramine functionalized carbon fiber with varying chain lengths
In order to understand the effects of chain length on the interfacial adhesion of PAN-based carbon fiber (CF)/epoxy composites, dendritic hexamethylenetetramine (HMTA) was functionalized on carbon


Hexamethylenetetramine–Bromine: A Novel Reagent for Selective Regeneration of Carbonyl Compounds from Oximes and Tosylhydrazones†‡
Hexamethylenetetramine–bromine (HMTAB) has been found to be an efficient and selective reagent for the mild oxidative cleavage of the CN of oximes and tosylhydrazones to yield their corresponding
A facile synthesis of naturally occurring 5-(3-indolyl)oxazoles
Abstract A simple and efficient synthesis of naturally occurring 5-(3-indolyl)oxazoles is described. The key steps of this convergent approach are the formation of a
Convenient, Easy and Highly Regioselective Preparation of Haloalcohols from the Reaction of Epoxides with Elemental Halogen Catalyzed by Hexamethylenetetramine (HMTA)
The highly regioselective cleavage of epoxides into corresponding vicinal haloalcohols with elemental halogen has been catalyzed by hexamethylenetetramine (HMTA). This method occurred under neutral
A New Application of Hexamethylenetetramine‐Bromine Supported onto Wet Alumina as an Efficient Reagent for Cleavage of Phenylhydrazones under Classical Heating and Microwave Irradiation
2,4-Dinitrophenylhydrazones were converted to their parent carbonyl compounds using hexamethylenetetramine-bromine complex supported onto wet alumina under classical heating and microwave irradiation.
New opportunities with the Duff reaction.
The formation of an aminomethyl intermediate in the Duff reaction mechanism is unequivocally demonstrated and provides a useful route to aldehydes for compounds bearing sensitive amide functions.
Reactions of alkyl (halomethyl)furancarboxylates with hexamethylenetetramine
All isomers of (aminomethyl)furancarboxylic acids were prepared by the Delepine reaction from alkyl (halomethyl)furancarboxylates. Treatment of the initially formed quaternary salt with an ethanolic
Synthesis of novel benzothiazole compounds with an extended conjugated system
Novel cyano-substituted benzothiazoles (Schemes 1 and 2) were synthesized, which possess an extended conjugated system. Compound 6 consists of two benzothiazole units with
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Tris-hydroxymethyl-phosphin (I) reagiert mit Urotropin (II) und Formaldehyd (III) zum Triaza-phospha-adamantan (IV), das mit Methyljodid zu (V) quaterniert wird.
Enantioselective catalytic epoxidation of cinnamate esters
Abstract A broad study of the (salen)Mn(III)-catalyzed asymmetric epoxidation of cis-cinnamate esters reveals that the steric properties of the ester group have a profound influence on
The Nitrosation of Hexamethylenetetramine and Related Compounds1
of the solution. pentamethylenetetramine. nitrosyl chloride and acetic anhydride on known compounds derived from hexamethylenetetramine. In connection with studies on the nitration of