An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women

@article{StanisawskaSachadyn2008AnIP,
  title={An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women},
  author={Anna Stanisławska-Sachadyn and Karen S. Brown and Laura E. Mitchell and Jayne V Woodside and Ian S Young and John M. Scott and Liam Murray and Colin A. Boreham and Helene McNulty and J. Robert Strain and Alexander Steven Whitehead},
  journal={Human Genetics},
  year={2008},
  volume={123},
  pages={289-295}
}
A low serum folate and high homocysteine phenotype is associated with an increased risk of neural tube defects (NTDs), cardiovascular diseases and other pathologies. Thus defining both genetic and non-genetic factors that may impact folate/homocysteine metabolism will enhance our understanding of the etiologic mechanisms underlying these conditions and facilitate risk assessment. Dihydrofolate reductase catalyzes the reduction of folic acid to dihydrofolate and thereafter to tetrahydrofolate… CONTINUE READING
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IdentiWcation of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene

  • SL Wardrop, Investigators kConFab, MA Brown
  • Genomics
  • 2005
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