An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura.

@article{Staropoli2009AnII,
  title={An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura.},
  author={John F. Staropoli and Christopher P Stowell and Hande H Tuncer and Marisa B. Marques},
  journal={Vox sanguinis},
  year={2009},
  volume={96 4},
  pages={344-8}
}
BACKGROUND AND OBJECTIVES ABO blood group accounts for up to 40% of the variability in plasma von Willebrand factor (VWF) levels, which vary in the rank order AB > B > A > O > Bombay. This may be due in part to the influence of ABO-associated oligosaccharides on the proteolysis of VWF by the metalloprotease ADAMTS13, which is markedly deficient in thrombotic thrombocytopenic purpura (TTP). Using ABO blood group as a surrogate for baseline VWF levels as well as susceptibility to proteolysis by… CONTINUE READING