An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses

Abstract

Phosphorylation of histone H3 at Ser10 increases chromatin accessibility to transcription factor NF-κB on a subset of genes involved in immune responses. Here we report that a bacterial pathogen abrogated phosphorylation of histone H3 to 'shape' the transcriptional responses of infected host cells. We identify the Shigella flexneri protein effector OspF as… (More)
DOI: 10.1038/ni1423

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