An inhibitory monoclonal antibody to human acetylcholinesterases.

  title={An inhibitory monoclonal antibody to human acetylcholinesterases.},
  author={Katrine Sorensen and Urs Brodbeck and Allan G Rasmussen and Bent Norgaard-Pedersen},
  journal={Biochimica et biophysica acta},
  volume={912 1},
The monoclonal antibody AE-2 raised against acetylcholinesterase (acetylcholine acetylhydrolase, EC from human erythrocytes is shown to inhibit the enzyme activity. The reaction of the antibody with a structural epitope is investigated further. The epitope resides on monomeric, dimeric and tetrameric species of the enzyme. The rate of phosphorylation of the enzyme by diisopropylfluorophosphate was not affected by the antibody. On the other hand, inhibitors directed towards the anionic… CONTINUE READING

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