An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide.

@article{Chen2010AnIO,
  title={An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide.},
  author={Feng Chen and David Fulton},
  journal={Molecular pharmacology},
  year={2010},
  volume={77 2},
  pages={
          280-7
        }
}
The methylation of proteins is an important post-translational mechanism that has been established to influence the activity of nuclear and nucleic acid binding proteins. Much less is known about the importance of protein methylation in the regulation of cytosolic proteins. Increased methylation of proteins is observed in cardiovascular disease and occurs in conjunction with elevated production of reactive oxygen species. However, the nature of the relationship between reactive oxygen species… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production.

  • Antioxidants & redox signaling
  • 2011
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species.

  • Free radical biology & medicine
  • 2014
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

ADMA and oxidative stress.

  • Atherosclerosis. Supplements
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Small molecule regulators of protein arginine methyltransferases.

  • The Journal of biological chemistry
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Do nitroxide antioxidants act as scavengers of O2-. or as SOD mimics?

  • The Journal of biological chemistry
  • 1996
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

In vivo turnover and distribution of radio-N-methyl in arginine-rich histones from rat tissues.

  • Archives of biochemistry and biophysics
  • 1972
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL