An inhibitor of polyamine biosynthesis impairs human polymorphonuclear leukocyte priming by tumor necrosis factor alpha.

@article{Walters1995AnIO,
  title={An inhibitor of polyamine biosynthesis impairs human polymorphonuclear leukocyte priming by tumor necrosis factor alpha.},
  author={John D. Walters and A C Cario and Binnaz Leblebicioglu and M Calvino Fern{\'a}ndez and Phillip T. Marucha},
  journal={Journal of leukocyte biology},
  year={1995},
  volume={57 2},
  pages={282-6}
}
TNF primes polymorphonuclear leukocytes (PMNs) for enhanced oxidative and secretory activity and directly induces adhesion and IL-1 beta expression. Previous reports suggest that polyamine biosynthesis by ornithine decarboxylase (ODC) has an essential role in macrophage activation by TNF. In the current study, TNF induced rapid increases in the putrescine and spermine content of PMNs. Difluoromethylornithine (DFMO), a selective inhibitor of ODC, inhibited these increases and blunted the… CONTINUE READING

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