An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.

@article{MacKay1999AnIO,
  title={An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia.},
  author={Karen Lynn MacKay and Daria Mochly-Rosen},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 10},
  pages={6272-9}
}
Cellular ischemia results in activation of a number of kinases, including p38 mitogen-activated protein kinase (MAPK); however, it is not yet clear whether p38 MAPK activation plays a role in cellular damage or is part of a protective response against ischemia. We have developed a model to study ischemia in cultured neonatal rat cardiac myocytes. In this model, two distinct phases of p38 MAPK activation were observed during ischemia. The first phase began within 10 min and lasted less than 1 h… CONTINUE READING

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