An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms.

Abstract

Specific inhibitors of glucosylceramide biosynthesis are used as drugs for the treatment of some human diseases correlated to glycosphingolipid metabolism. The target of the presently available inhibitors is the human glucosylceramide synthase (GCS), but effects on enzymes from other organisms have not been studied. We expressed cDNAs encoding GCS enzymes… (More)

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@article{Hillig2005AnIO, title={An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms.}, author={Inga Hillig and Dirk C. Warnecke and E. Ralph Heinz}, journal={Bioscience, biotechnology, and biochemistry}, year={2005}, volume={69 9}, pages={1782-5} }