An inhibitor of endopeptidase-24.15 blocks the degradation of intraventricularly administered dynorphins.

@article{Molineaux1990AnIO,
  title={An inhibitor of endopeptidase-24.15 blocks the degradation of intraventricularly administered dynorphins.},
  author={Christopher J. Molineaux and Julia Marie Ayala},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 2},
  pages={611-8}
}
Conversion of the octapeptide dynorphin (Dyn) A-(1-8) to Leu5-enkephalin (LE) by endopeptidase EC 3.4.24.15 (EP-24.15) in vivo was examined using the technique of ventriculocisternal perfusion. Peptides were administered intracerebroventricularly in the presence or absence of the EP-24.15 inhibitor N-[1-(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFPAAF-pAB) via cannulae placed into the lateral ventricle of urethane-anesthetized rats. The concentration of Dyn-like peptides and LE… CONTINUE READING