An inhibitor of cell proliferation associated with adhesion formation is suppressed by N,O-carboxymethyl chitosan.

@article{Krause1998AnIO,
  title={An inhibitor of cell proliferation associated with adhesion formation is suppressed by N,O-carboxymethyl chitosan.},
  author={Tyrone J Krause and Noriko K Goldsmith and Susanne Ebner and G. A. Zazanis and Randall D Mckinnon},
  journal={Journal of investigative surgery : the official journal of the Academy of Surgical Research},
  year={1998},
  volume={11 2},
  pages={
          105-13
        }
}
Surgical adhesions are a major cause of morbidity and mortality. The ideal barrier agent will both minimize adhesions and provide a milieu for the regeneration of the mesothelium lining of the abdominal and thoracic cavities. N,O-Carboxymethylchitosan (NOCC), a derivation of chitin that markedly reduces adhesions, may function to modulate intracellular signals such as growth factors and cytokines in the inflammatory exudate. Since transforming growth factor-beta is implicated in the fibrotic… CONTINUE READING

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