An inhibitor of Bcl-2 family proteins induces regression of solid tumours

  title={An inhibitor of Bcl-2 family proteins induces regression of solid tumours},
  author={Tilman Oltersdorf and Steven W. Elmore and Alexander R. Shoemaker and Robert C. Armstrong and David J. Augeri and Barbara A. Belli and Milan Bruncko and Thomas L. Deckwerth and Jurgen Dinges and Philip J. Hajduk and Mary K. Joseph and Shinichi Kitada and S Stanley J. Korsmeyer and Aaron R. Kunzer and Anthony Letai and Chi Li and Michael J. Mitten and David G. Nettesheim and Shichung Ng and Paul M. Nimmer and J M O'connor and Anatol X Oleksijew and Andrew M. Petros and John C. Reed and Wang Jin Shen and Stephen K. Tahir and Craig B Thompson and Kevin J. Tomaselli and Baole Wang and Michael D. Wendt and Haichao Zhang and Stephen W. Fesik and Saul H. Rosenberg},
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed in many cancers and contribute to tumour initiation, progression and resistance to therapy. Bcl-XL expression correlates with chemo-resistance of tumour cell lines, and reductions in Bcl-2 increase sensitivity to anticancer drugs and enhance in vivo survival. The development of inhibitors of these proteins as potential anti-cancer… CONTINUE READING
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