An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental lung injury.

@article{Hartmann2013AnIT,
  title={An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental lung injury.},
  author={Erik Kristopher Hartmann and Stefan Boehme and Bastian Duenges and A Bentley and Klaus Ulrich Klein and Robert Kwiecien and Chen Shi and Marc Szczyrba and Matthias David and Klaus Markstaller},
  journal={Acta anaesthesiologica Scandinavica},
  year={2013},
  volume={57 3},
  pages={334-41}
}
INTRODUCTION The lectin-like domain of TNF-α enhances the fluid clearance across the alveolar barrier. For experimental purposes, the lectin-like domain can be mimicked by a synthetic peptide representing the TIP-motif of TNF-α. The present study aims to assess the acute effect of TIP on the pulmonary function in a porcine model of acute respiratory distress syndrome (ARDS). METHODS Lung injury was induced in 16 pigs (25-27 kg) by bronchoalveolar lavage followed by injurious ventilation… CONTINUE READING
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