An information-gain approach to detecting three-way epistatic interactions in genetic association studies

@inproceedings{Hu2013AnIA,
  title={An information-gain approach to detecting three-way epistatic interactions in genetic association studies},
  author={Ting Hu and Yuanzhu Peter Chen and Jeff Kiralis and Ryan L. Collins and Christian Wejse and Giorgio Sirugo and Scott M. Williams and Jason H. Moore},
  booktitle={JAMIA},
  year={2013}
}
BACKGROUND Epistasis has been historically used to describe the phenomenon that the effect of a given gene on a phenotype can be dependent on one or more other genes, and is an essential element for understanding the association between genetic and phenotypic variations. Quantifying epistasis of orders higher than two is very challenging due to both the computational complexity of enumerating all possible combinations in genome-wide data and the lack of efficient and effective methodologies… CONTINUE READING
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