An inflammatory pathway of IFN-gamma production in coronary atherosclerosis.

  title={An inflammatory pathway of IFN-gamma production in coronary atherosclerosis.},
  author={Hooman Ranjbaran and Seth I. Sokol and Amy M Gallo and Raymond E. Eid and Alexander O Iakimov and Alessio D'Alessio and John R. Kapoor and Shamsuddin Akhtar and Christopher J.A. Howes and Mihaela Aslan and Steven Pfau and Jordan S Pober and George Tellides},
  journal={Journal of immunology},
  volume={178 1},
Inflammation is associated with the pathogenesis of coronary atherosclerosis, although the mechanisms remain unclear. We investigated whether cytokine secretion by innate immune responses could contribute to the production of proarteriosclerotic Th1-type cytokines in human coronary atherosclerosis. Cytokines were measured by ELISA in the plasma of patients with coronary atherosclerosis undergoing cardiac catheterization. IL-18 was detected in all subjects, whereas a subset of patients… CONTINUE READING


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