An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis.

@article{Ray2008AnIT,
  title={An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis.},
  author={Alpana Ray and B. K. Ray},
  journal={Biorheology},
  year={2008},
  volume={45 3-4},
  pages={399-409}
}
A number of risk factors including biomechanical stress on the articular cartilage imposed by joint overloading due to obesity, repetitive damage of the joint tissues by injury of the menisci and ligaments, and abnormal joint alignment play a significant role in the onset of osteoarthritis (OA). Genetic predisposition can also lead to the formation of defective cartilage matrix because of abnormal gene expression in the cartilage-specific cells. Another important biochemical event in OA is the… CONTINUE READING