An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.

@article{Dong2007AnIR,
  title={An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.},
  author={Beihua Dong and Sanggu Kim and Seunghee Hong and Jaydip Das Gupta and Krishnamurthy Malathi and Eric A Klein and Donald E Ganem and Joseph L. DeRisi and Samson A. Chow and Robert H. Silverman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 5},
  pages={1655-60}
}
We recently reported identification of a previously undescribed gammaretrovirus genome, xenotropic murine leukemia virus-related virus (XMRV), in prostate cancer tissue from patients homozygous for a reduced activity variant of the antiviral enzyme RNase L. Here we constructed a full-length XMRV genome from prostate tissue RNA and showed that the molecular viral clone is replication-competent. XMRV replication in the prostate cancer cell line DU145 was sensitive to inhibition by IFN-beta… CONTINUE READING
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