An infant mouse model of brain damage in pneumococcal meningitis

  title={An infant mouse model of brain damage in pneumococcal meningitis},
  author={Denis Grandgirard and Oliver Steiner and Martin George T{\"a}uber and Stephen L Leib},
  journal={Acta Neuropathologica},
Bacterial meningitis due to Streptococcus pneumoniae is associated with an significant mortality rate and persisting neurologic sequelae including sensory-motor deficits, seizures, and impairments of learning and memory. The histomorphological correlate of these sequelae is a pattern of brain damage characterized by necrotic tissue damage in the cerebral cortex and apoptosis of neurons in the hippocampal dentate gyrus. Different animal models of pneumococcal meningitis have been developed to… CONTINUE READING


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