An infant mouse model of brain damage in pneumococcal meningitis

  title={An infant mouse model of brain damage in pneumococcal meningitis},
  author={D. Grandgirard and O. Steiner and M. T{\"a}uber and S. Leib},
  journal={Acta Neuropathologica},
  • D. Grandgirard, O. Steiner, +1 author S. Leib
  • Published 2007
  • Medicine
  • Acta Neuropathologica
  • Bacterial meningitis due to Streptococcus pneumoniae is associated with an significant mortality rate and persisting neurologic sequelae including sensory-motor deficits, seizures, and impairments of learning and memory. The histomorphological correlate of these sequelae is a pattern of brain damage characterized by necrotic tissue damage in the cerebral cortex and apoptosis of neurons in the hippocampal dentate gyrus. Different animal models of pneumococcal meningitis have been developed to… CONTINUE READING
    Pneumococcal meningitis induced neuronal injury in motor cortex and cerebellum in Wistar rats
    Pathophysiology of pneumococcal meningitis
    • 1
    • Open Access
    Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis
    • 14
    Acetylcholinesterase activity in the rat brain after pneumococcal meningitis


    Publications referenced by this paper.
    A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
    • 98
    Hematogenous pneumococcal meningitis in the infant rat: description of a model.
    • 36
    Pathogenesis and pathophysiology of pneumococcal meningitis.
    • 553
    Method for inducing experimental pneumococcal meningitis in outbred mice
    • 23
    • Open Access