An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.

@article{Forrester1996AnIG,
  title={An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.},
  author={Lesley M Forrester and Andras D Nagy and Mehran Sam and Alistair Watt and Lauren Stevenson and Alan Bernstein and Alexandra L. Joyner and Wolfgang Wurst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 4},
  pages={1677-82}
}
We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of receptor/ligand-mediated signaling pathways. Using this approach, we have identified 20 gene trap integrations in embryonic stem cells, 9 of which were induced and 11 of which were repressed after exposure to exogenous retinoic acid (RA). All but one of these integrations showed unique spatially restricted or tissue-specific patterns of expression between 8.5 and 11… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system.

Developmental dynamics : an official publication of the American Association of Anatomists • 1998
View 4 Excerpts
Highly Influenced

Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro

Kazuhiro Yagitaa, Kyoji Horiec, +8 authors Yasuo Uchiyamag
2010
View 1 Excerpt

Similar Papers

Loading similar papers…