An individualized prognostic signature for gastric cancer patients treated with 5-Fluorouracil-based chemotherapy and distinct multi-omics characteristics of prognostic groups

@inproceedings{Li2016AnIP,
  title={An individualized prognostic signature for gastric cancer patients treated with 5-Fluorouracil-based chemotherapy and distinct multi-omics characteristics of prognostic groups},
  author={Xiangyu Li and Hao Cai and Weicheng Zheng and Mengsha Tong and Hongdong Li and Lu Ao and Jing Li and Guini Hong and Mengyao Li and Qingzhou Guan and Sheng Yang and Da Yang and Xu Lin and Zheng Guo},
  booktitle={Oncotarget},
  year={2016}
}
5-Fluorouracil (5-FU)-based chemotherapy is currently the first-line treatment for gastric cancer. In this study, using gene expression profiles for a panel of cell lines with drug sensitivity data and two cohorts of patients, we extracted a signature consisting of two gene pairs (KCNE2 and API5, KCNE2 and PRPF3) whose within-sample relative expression orderings (REOs) could robustly predict prognoses of gastric cancer patients treated with 5-FU-based chemotherapy. This REOs-based signature was… CONTINUE READING

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