An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.

@article{Kamiya2004AnIR,
  title={An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.},
  author={Sadahiro Kamiya and Toshiyuki Owaki and Noriko Morishima and Fumio Fukai and Junichiro Mizuguchi and Takayuki Yoshimoto},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={
          3871-7
        }
}
IL-27 is a novel IL-12 family member that plays a role in the early regulation of Th1 initiation, induces proliferation of naive CD4+ T cells, and synergizes with IL-12 in IFN-gamma production. It has been recently reported that IL-27 induces T-bet and IL-12Rbeta2 expression through JAK1/STAT1 activation. In the present study, we further investigated the JAK/STAT signaling molecules activated by IL-27 and also the role of STAT1 in IL-27-mediated responses using STAT1-deficient mice. In addition… CONTINUE READING
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